New ways to find and treat multiple myeloma using CD46
Development of CD46 theranostics for imaging and treatment of multiple myeloma
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11118813
This project aims to create new ways to both see and treat multiple myeloma by targeting a specific protein called CD46.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11118813 on ClinicalTrials.gov |
What this research studies
We are working on special agents that can attach to a protein called CD46, which is found in high amounts on multiple myeloma cells. These agents can then be used in two ways: one for imaging to help doctors see where the cancer is, and another for delivering treatment directly to the cancer cells. We will first test these new agents in lab models and then in a small group of patients to see how well they work. Our goal is to find better ways to detect and fight multiple myeloma.
Who could benefit from this research
Good fit: Patients with multiple myeloma who may be eligible for a pilot imaging study could be ideal candidates.
Not a fit: Patients without multiple myeloma or those not suitable for the specific imaging or treatment approaches being developed may not receive direct benefit from this particular research.
Why it matters
Potential benefit: If successful, this could lead to more precise ways to detect multiple myeloma and deliver targeted treatments, potentially improving patient outcomes.
How similar studies have performed: A related antibody-drug conjugate targeting CD46 is currently in early-stage clinical trials, suggesting promise for this approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FLAVELL, ROBERT RICHARD — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FLAVELL, ROBERT RICHARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.