New ways to detect and monitor small vessel brain disease
Official title: Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular Disease
Funded at University of California, San Francisco · NIH-10913293 · Data updated 2026-11-12
This study is looking at new ways to spot and track small vessel brain problems that can affect memory in older adults, and it's for anyone interested in improving how we diagnose and treat these issues, especially those related to Alzheimer's disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 29, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,050,008 |
| NIH project number | 5U01NS100608-08 |
| Project ID | NIH-10913293 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cognitive decline and related cerebrovascular issues.
✕Less likely to help
Patients who are younger or do not exhibit symptoms of cognitive decline or cerebrovascular disease may not benefit from this research.
What this research studies
This research focuses on small vessel cerebrovascular disease, which is common in older adults and contributes to cognitive decline. The study aims to validate new imaging techniques and fluid-based biomarkers that can help in the early detection and monitoring of this condition. By following a diverse group of 200 older participants, the research will assess the relationship between these biomarkers and Alzheimer's disease. The goal is to enhance diagnosis and treatment outcomes for patients suffering from cerebrovascular issues.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for patients with small vessel cerebrovascular disease.
How similar studies have gone: Previous research has shown promise in using imaging and biomarkers for cerebrovascular diseases, indicating that this approach has potential for success.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Kramer, Joel H — University of California, San Francisco
- Study coordinator: Kramer, Joel H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.