New ways to create antibiotics to fight resistant bacteria.
Innovative technologies to transform antibiotic discovery. Project 3 Rapid Access to Antibiotic Biosynthesis Machinery Using Synthetic Biology
This study is working on new ways to find antibiotics that can fight tough bacteria that don't respond to current medicines, so that patients can have better treatment options for infections that are hard to treat.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10670193 on NIH RePORTER |
What this research studies
This research focuses on developing innovative technologies to discover new antibiotics, particularly targeting Gram-negative bacteria that are resistant to current treatments. By utilizing synthetic biology, the project aims to produce large libraries of potential antimicrobial molecules and screen them against harmful pathogens. The approach involves creating cell-free systems that can efficiently synthesize antibiotic compounds, overcoming traditional challenges in antibiotic discovery. Patients may benefit from new treatment options that could effectively combat antibiotic-resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by Gram-negative bacteria, particularly those who have not responded to existing antibiotic treatments.
Not a fit: Patients with infections caused by Gram-positive bacteria or those who do not have bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections caused by resistant bacteria.
How similar studies have performed: Other research has shown promise in using synthetic biology for antibiotic discovery, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Nicol, Robert — Broad Institute, INC.
- Study coordinator: Nicol, Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.