New ways cells communicate to affect health
Novel mechanisms in the control of cAMP dynamics
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11126838
This research explores how signals inside our cells contribute to conditions like chronic inflammation, pain, and migraine.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11126838 on ClinicalTrials.gov |
What this research studies
Our bodies rely on special cell receptors called GPCRs, which are targeted by many common medicines. Traditionally, we thought these signals only came from the cell's outer surface. However, we now know that these signals can also come from inside the cell, and these internal signals are linked to long-lasting conditions such as chronic inflammation, pain, and migraine. This project aims to uncover the hidden ways these internal cell signals work, focusing on a newly discovered regulatory unit. By understanding these mechanisms, we hope to find new approaches for treating these challenging conditions.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals living with chronic inflammation, chronic pain, or migraine, as it seeks to understand the underlying cellular processes of these conditions.
Not a fit: Patients whose conditions are not related to GPCR or cAMP signaling pathways may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatment strategies for chronic inflammation, chronic pain, and migraine by targeting these internal cell signaling pathways.
How similar studies have performed: This research explores novel and previously unknown mechanisms of cell signaling, building on recent challenges to traditional understanding.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALTSCHULER, DANIEL L — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: ALTSCHULER, DANIEL L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.