New way to target a kidney transporter to slow ADPKD cyst growth
Official title: Novel approach to target Na,K-ATPase to slow renal cystogenesis
Funded at University of Kansas Medical Center · NIH-11447600 · Data updated 2026-11-12
A patient-focused look at a new approach that targets a kidney transporter to slow cyst growth in autosomal dominant polycystic kidney disease (ADPKD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $334,627 |
| NIH project number | 1R01DK144183-01A1 |
| Project ID | NIH-11447600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with autosomal dominant polycystic kidney disease who have evidence of cyst growth and kidney function decline.
✕Less likely to help
Patients without ADPKD or those not experiencing cyst growth may not benefit from this specific approach.
What this research studies
This project explores whether modulating the Na,K-ATPase transporter in kidney cells can reduce cyst formation and preserve kidney function in ADPKD. Researchers have identified that ouabain-like substances in the blood may drive cyst growth through this transporter, and they plan to test how altering the transporter’s interaction with ouabain could slow disease progression. The study uses human kidney cyst cells and animal models to understand signaling that leads to cell proliferation and fluid buildup inside cysts, aiming to translate findings into potential therapies. If successful, the work could inform treatments that reduce cyst growth and protect kidney function for people living with ADPKD.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that slow cyst growth and help maintain kidney function in ADPKD.
How similar studies have gone: Previous findings show that targeting cellular signaling can influence cyst growth, suggesting potential for this approach, though human translation is being explored.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Blanco, V Gustavo — University of Kansas Medical Center
- Study coordinator: Blanco, V Gustavo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.