New Virus Therapy for Glioblastoma Brain Tumors
Next Gen Virotherapy for GBM
['FUNDING_R01'] · AUGUSTA UNIVERSITY · NIH-11144464
This research explores a new way to fight glioblastoma brain tumors by combining a virus treatment with a strategy to block a protein called NOTCH.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-11144464 on ClinicalTrials.gov |
What this research studies
Glioblastoma (GBM) is a very aggressive brain tumor that is hard to treat, often resisting current therapies like chemotherapy and radiation. This project aims to improve treatment by using a special virus, called oHSV, which is designed to attack cancer cells. We believe that blocking a protein called NOTCH, which helps GBM tumors resist treatment, could make the virus therapy even more effective. Our goal is to safely deliver this combined approach directly into the brain to enhance the virus's ability to fight the tumor while minimizing side effects. We are also looking into how blocking NOTCH might affect memory and overall brain safety.
Who could benefit from this research
Good fit: Patients with glioblastoma brain tumors who have limited treatment options or whose tumors have become resistant to standard therapies might be ideal candidates for future studies based on this research.
Not a fit: Patients without glioblastoma or those whose tumors are not driven by the NOTCH pathway may not directly benefit from this specific treatment approach.
Why it matters
Potential benefit: If successful, this approach could offer a more effective treatment option for glioblastoma patients, potentially improving survival and quality of life.
How similar studies have performed: While virus-based therapies for cancer are being explored, this specific combination of an oncolytic virus with a NOTCH-blocking strategy for glioblastoma is a novel approach.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAUR, BALVEEN — AUGUSTA UNIVERSITY
- Study coordinator: KAUR, BALVEEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.