New vaccines for better protection against whooping cough
Official title: Novel B. Pertussis vaccines that elicit mucosal immunity
Funded at Ohio State University · NIH-11131535 · Data updated 2026-11-12
This study is working on a new whooping cough vaccine that aims to boost your immune system in the nose and lungs, helping to stop the spread of the infection and provide longer-lasting protection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 6, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $657,506 |
| NIH project number | 1R56AI183683-01 |
| Project ID | NIH-11131535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of all ages, particularly those who have been vaccinated against whooping cough but are still at risk of infection.
✕Less likely to help
Patients who have not been vaccinated against whooping cough or those with severe immunocompromised conditions may not benefit from this research.
What this research studies
This research focuses on developing a new type of vaccine for whooping cough caused by Bordetella pertussis. It aims to create a subunit vaccine that elicits strong immune responses in the nose and lungs, which are crucial for preventing the spread of the infection. By using specific adjuvants that enhance the immune response, the researchers hope to generate long-lasting immunity that can effectively clear the bacteria from the respiratory tract. This approach is designed to address the limitations of current acellular vaccines that do not prevent nasal colonization.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide better protection against whooping cough, reducing transmission and improving public health.
How similar studies have gone: Other research has shown promise in developing vaccines that elicit strong mucosal immunity, suggesting that this approach could be effective.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Dubey, Purnima — Ohio State University
- Study coordinator: Dubey, Purnima
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.