New vaccines for better protection against whooping cough
Novel B. Pertussis vaccines that elicit mucosal immunity
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-11131535
This study is working on a new whooping cough vaccine that aims to boost your immune system in the nose and lungs, helping to stop the spread of the infection and provide longer-lasting protection.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11131535 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new type of vaccine for whooping cough caused by Bordetella pertussis. It aims to create a subunit vaccine that elicits strong immune responses in the nose and lungs, which are crucial for preventing the spread of the infection. By using specific adjuvants that enhance the immune response, the researchers hope to generate long-lasting immunity that can effectively clear the bacteria from the respiratory tract. This approach is designed to address the limitations of current acellular vaccines that do not prevent nasal colonization.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of all ages, particularly those who have been vaccinated against whooping cough but are still at risk of infection.
Not a fit: Patients who have not been vaccinated against whooping cough or those with severe immunocompromised conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide better protection against whooping cough, reducing transmission and improving public health.
How similar studies have performed: Other research has shown promise in developing vaccines that elicit strong mucosal immunity, suggesting that this approach could be effective.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUBEY, PURNIMA — OHIO STATE UNIVERSITY
- Study coordinator: DUBEY, PURNIMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.