New urine test to analyze circular DNA for cancer diagnosis
Novel Technologies to Isolate and Analyze Extrachromosomal DNAs for Diagnostic Applications
This study is working on a new urine test that looks for special pieces of DNA that can help us learn more about diseases like cancer, with the hope of creating better ways to diagnose and treat these conditions.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Phinomics INC. NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project ID | NIH-10895626 on NIH RePORTER |
What this research studies
This research focuses on developing a novel urine-based test to isolate and analyze extrachromosomal circular DNA (eccDNA), which are unique DNA elements that can provide insights into various diseases, including cancers. By utilizing advanced sequencing and bioinformatics techniques, the study aims to better understand the role of eccDNA in human health and disease. The goal is to create a diagnostic tool that can identify disease-specific eccDNA, potentially leading to improved cancer diagnostics and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with suspected cancers or those undergoing diagnostic evaluations for bladder cancer.
Not a fit: Patients who do not have cancer or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and non-invasive diagnostic methods for detecting cancers and other diseases.
How similar studies have performed: While the approach of analyzing eccDNA is relatively novel, similar methodologies in cancer diagnostics have shown promise in other contexts.
Where this research is happening
Palo Alto, United States
- Phinomics INC. — Palo Alto, United States (Active)
Researchers
- Principal investigator: Shoura, Massa J. — Phinomics INC.
- Study coordinator: Shoura, Massa J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.