New trial designs for Alzheimer's disease challenges
Alzheimer's Disease: New Trial Designs for Emerging Challenges
This study is looking at ways to make Alzheimer's disease clinical trials better by considering different factors like sex, race, and genetics, especially for patients with a specific genetic marker, to help find more effective treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11004166 on NIH RePORTER |
What this research studies
This research focuses on improving clinical trial designs for Alzheimer's disease (AD) by addressing the unique challenges faced by different patient populations, particularly considering factors like sex, race, and genetic markers. The study aims to develop adaptive trial designs that allow for modifications in follow-up times based on changes in treatment dosages, specifically for APOE ε4 positive patients. By utilizing data from previous trials, the researchers will simulate and compare the effectiveness of these new designs against traditional methods. This approach seeks to enhance the accuracy and reliability of trial outcomes, ultimately benefiting patients with AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those who are APOE ε4 positive or belong to diverse racial and ethnic backgrounds.
Not a fit: Patients with early-stage Alzheimer's disease or those not meeting the specific criteria for APOE ε4 status may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective clinical trials for Alzheimer's disease, improving treatment options and outcomes for patients.
How similar studies have performed: Previous research has shown that adaptive trial designs can improve the efficiency and effectiveness of clinical trials, indicating a promising avenue for this approach in Alzheimer's disease.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Shan, Guogen — University of Florida
- Study coordinator: Shan, Guogen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.