New treatments to reduce tissue damage in rheumatoid arthritis
Official title: Establishing novel therapeutic strategies to target RA pannus formation
Funded at Jesse Brown VA Medical Center · NIH-10801167 · Data updated 2026-11-12
This study is looking for new ways to help veterans with rheumatoid arthritis who haven't found relief from current treatments by exploring how to better protect their joints from damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| NIH project number | 1I01CX002565-01A2 |
| Project ID | NIH-10801167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis, particularly those who have not responded to current treatment options.
✕Less likely to help
Patients with rheumatoid arthritis who are currently responding well to existing treatments may not benefit from this research.
What this research studies
This research focuses on developing innovative therapies for rheumatoid arthritis (RA), a chronic autoimmune disease that affects millions, particularly veterans. The project aims to identify new therapeutic targets for patients who do not respond to existing treatments by exploring unique pathways that alleviate tissue damage. By disconnecting inflammatory macrophages from joint blood vessels through metabolic reprogramming, the research seeks to improve patient outcomes and quality of life. The approach is designed to impact multiple cell types involved in RA, offering a broader mechanism of action than current therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for rheumatoid arthritis, significantly improving the quality of life for patients.
How similar studies have gone: While this approach is innovative, similar research has shown promise in targeting metabolic pathways to improve treatment outcomes in autoimmune diseases.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Shahrara, Shiva — Jesse Brown VA Medical Center
- Study coordinator: Shahrara, Shiva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.