New treatments to fight infections caused by Pseudomonas aeruginosa
Official title: Novel Antibiofilm Treatments for Pseudomonas aeruginosa Infection
Funded at Michigan State University · NIH-10795063 · Data updated 2026-11-12
This study is looking for new ways to help people with tough infections caused by a germ called Pseudomonas aeruginosa, which can be hard to treat because it forms a protective layer; researchers are testing lots of different natural and existing medicines to find combinations that can break through this layer and work better together.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | March 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,884 |
| NIH project number | 5R03AI176255-02 |
| Project ID | NIH-10795063 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from infections caused by Pseudomonas aeruginosa, particularly those with antibiotic-resistant strains.
✕Less likely to help
Patients with infections caused by bacteria other than Pseudomonas aeruginosa may not benefit from this research.
What this research studies
This research focuses on developing innovative treatments to combat infections caused by Pseudomonas aeruginosa, a bacterium known for forming protective biofilms that make it resistant to antibiotics. The researchers are using high throughput screening to test thousands of compounds, including plant extracts and existing antibiotics, to find combinations that can effectively break down these biofilms. By identifying synergistic effects between these compounds and traditional antibiotics, the goal is to enhance treatment efficacy for patients suffering from these difficult infections.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with antibiotic-resistant infections, potentially reducing morbidity and mortality associated with these conditions.
How similar studies have gone: Previous research has shown promise in using synergistic approaches to combat antibiotic-resistant infections, suggesting that this method could be effective.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Hardy, Jonathan W — Michigan State University
- Study coordinator: Hardy, Jonathan W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.