New treatments targeting the causes of atrial fibrillation
New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial Fibrillation
This study is looking into the causes of atrial fibrillation, a heart rhythm problem that many older adults face, to find better treatments that tackle the root of the issue instead of just the symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11251668 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular mechanisms that lead to atrial fibrillation (AF), a common heart rhythm disorder affecting millions, particularly the elderly. The team at Northwestern University aims to develop new therapeutic approaches that specifically target the underlying causes of AF, rather than just its symptoms. By studying the role of the autonomic nervous system and other molecular factors, they hope to create more effective treatments for patients with persistent AF. This work involves advanced animal models to explore how these mechanisms contribute to the progression of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults suffering from persistent atrial fibrillation.
Not a fit: Patients with atrial fibrillation who are not experiencing persistent symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for atrial fibrillation, improving heart health and reducing the risk of stroke for patients.
How similar studies have performed: Previous research has shown promise in targeting molecular mechanisms for heart rhythm disorders, suggesting potential for success in this novel approach.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Arora, Rishi — University of Chicago
- Study coordinator: Arora, Rishi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.