New treatments targeting immune cells in brain cancer
Developing Novel Therapeutic Approaches Targeting Macrophages in GBM
This study is looking at how certain immune cells help glioblastoma, a tough type of brain cancer, grow and spread, with the hope of finding better treatment options that could work alongside current therapies to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10894826 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma (GBM), a highly aggressive brain cancer with limited treatment options. The team is investigating how certain immune cells, specifically tumor-associated macrophages, contribute to the growth and spread of GBM. They aim to understand the mechanisms that lead to the recruitment and activation of these macrophages and explore new therapeutic strategies that combine existing treatments with novel approaches targeting these immune cells. Patients may benefit from improved treatment options that could enhance their response to therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those with specific genetic mutations like PTEN.
Not a fit: Patients with other types of brain tumors or those who do not have glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with glioblastoma, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in targeting immune cells in cancer treatment, suggesting that this approach could be beneficial for glioblastoma as well.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Wang, Y. Alan — Indiana University Indianapolis
- Study coordinator: Wang, Y. Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.