New treatments targeting gene expression changes in cancer
Epigenetic Therapies - New Approaches
This study is looking at new treatments for cancer that change how genes work, especially for patients with breast cancer, to help make current therapies more effective and tackle any resistance to them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coriell Institute for Medical Research NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project ID | NIH-10886773 on NIH RePORTER |
What this research studies
This research focuses on epigenetic therapies that aim to modify gene expression patterns to treat cancer. By understanding how DNA methylation and chromatin remodeling influence cancer development and treatment resistance, the researchers are exploring new therapeutic approaches. The study involves testing various drugs that target specific epigenetic mechanisms, with the goal of improving patient outcomes in cancers like breast cancer. Patients may benefit from innovative treatments that could enhance the effectiveness of existing therapies or overcome resistance to them.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer or other cancers that may benefit from epigenetic therapies.
Not a fit: Patients with non-cancerous conditions or those whose cancers are not influenced by epigenetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that improve survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown success with epigenetic therapies, leading to FDA approvals for several drugs targeting epigenetic modifications.
Where this research is happening
Camden, United States
- Coriell Institute for Medical Research — Camden, United States (Active)
Researchers
- Principal investigator: Issa, Jean-Pierre J. — Coriell Institute for Medical Research
- Study coordinator: Issa, Jean-Pierre J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.