New treatments targeting gene expression changes in cancer
Official title: Epigenetic Therapies - New Approaches
Funded at Coriell Institute for Medical Research · NIH-10886773 · Data updated 2026-11-12
This study is looking at new treatments for cancer that change how genes work, especially for patients with breast cancer, to help make current therapies more effective and tackle any resistance to them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coriell Institute for Medical Research NIH-funded |
| Lab location | 1 site (Camden, United States) |
| Project start | August 16, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $2,421,039 |
| NIH project number | 5P50CA254897-04 |
| Project ID | NIH-10886773 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with breast cancer or other cancers that may benefit from epigenetic therapies.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers are not influenced by epigenetic factors may not benefit from this research.
What this research studies
This research focuses on epigenetic therapies that aim to modify gene expression patterns to treat cancer. By understanding how DNA methylation and chromatin remodeling influence cancer development and treatment resistance, the researchers are exploring new therapeutic approaches. The study involves testing various drugs that target specific epigenetic mechanisms, with the goal of improving patient outcomes in cancers like breast cancer. Patients may benefit from innovative treatments that could enhance the effectiveness of existing therapies or overcome resistance to them.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that improve survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown success with epigenetic therapies, leading to FDA approvals for several drugs targeting epigenetic modifications.
Where this research is happening
-
Coriell Institute for Medical Research
Camden, United States Active
Researchers
- Principal investigator: Issa, Jean-Pierre J. — Coriell Institute for Medical Research
- Study coordinator: Issa, Jean-Pierre J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.