New treatments for severe alcoholic hepatitis and preventing relapse
Novel Therapies for Alcoholic Hepatitis with Sepsis and for Relapse Prevention
This study is looking at whether giving high doses of vitamin C along with antibiotics can help people with severe alcoholic hepatitis and infections feel better and recover more safely.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10428495 on NIH RePORTER |
What this research studies
This research investigates new therapies for patients suffering from severe alcoholic hepatitis, particularly those who also have infections and sepsis. The approach involves administering high doses of vitamin C intravenously alongside antibiotics to see if it can safely reduce inflammation and improve outcomes. The study aims to demonstrate that this combination therapy is effective in treating both alcoholic hepatitis and the associated infections, which are major causes of mortality in these patients. By addressing these critical barriers, the research hopes to pave the way for new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with severe alcoholic hepatitis who are experiencing active infections or sepsis.
Not a fit: Patients with mild alcoholic hepatitis or those without active infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective treatments for severe alcoholic hepatitis, potentially reducing mortality and improving recovery rates.
How similar studies have performed: Previous research has shown promising results using vitamin C in similar critically ill populations, suggesting potential for success in this novel application.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Sanyal, Arun J — Virginia Commonwealth University
- Study coordinator: Sanyal, Arun J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.