New treatments for severe alcohol-related liver disease
Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) - Indiana University Data Coordinating Center
This study is looking for new treatments for people with serious liver problems caused by alcohol, like severe alcohol-related hepatitis and cirrhosis, and it’s inviting patients to help test these potential therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11078028 on NIH RePORTER |
What this research studies
This research focuses on developing effective therapies for advanced alcohol-associated liver disease, specifically severe alcohol-associated hepatitis and decompensated cirrhosis. The project involves conducting two proof-of-concept randomized controlled trials to test potential treatments for patients who are eligible or ineligible for steroid therapy. The Data Coordinating Center will provide essential support for these trials, including data management and biosample collection, to ensure high-quality research outcomes. Patients participating in this research may contribute to the advancement of treatment options for these serious liver conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with severe alcohol-associated hepatitis or decompensated cirrhosis.
Not a fit: Patients with mild liver disease or those not suffering from alcohol-related liver conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new FDA-approved therapies for severe alcohol-related liver disease, improving patient outcomes and quality of life.
How similar studies have performed: Previous research efforts in the Alcoholic Hepatitis Network have shown promise in developing treatments for alcohol-related liver diseases, indicating a foundation for potential success in this new initiative.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Tu, Wanzhu — Indiana University Indianapolis
- Study coordinator: Tu, Wanzhu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.