New treatments for pancreatitis using ubiquitin pathway modulators
Official title: Ubiquitin pathway modulators for treating pancreatitis
Funded at Progenra, INC. · NIH-10824472 · Data updated 2026-11-12
This study is looking at new ways to help people with acute and chronic pancreatitis by finding treatments that support healthy cell function, and it aims to test new compounds to see how well they work in improving this condition.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Progenra, INC. NIH-funded |
| Lab location | 1 site (Malvern, United States) |
| Project start | September 20, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $269,622 |
| NIH project number | 1R43DK138712-01 |
| Project ID | NIH-10824472 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from acute or chronic pancreatitis.
✕Less likely to help
Patients with pancreatitis caused by non-biological factors or those who do not respond to existing treatments may not benefit from this research.
What this research studies
This research focuses on developing new treatments for acute and chronic pancreatitis by promoting mitochondrial health. The approach involves activating the ubiquitin proteasome system, which plays a crucial role in clearing damaged mitochondria. Researchers will evaluate novel compounds for their effectiveness in cellular and animal models of pancreatitis, aiming to understand their mechanisms of action. The ultimate goal is to create small molecule drugs that can effectively treat this condition.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly improve the management of pancreatitis.
How similar studies have gone: Previous research has shown promise in using similar approaches to enhance mitochondrial health and treat related conditions, indicating potential for success in this area.
Where this research is happening
-
Progenra, INC.
Malvern, United States Active
Researchers
- Principal investigator: Suresh, Kumar — Progenra, INC.
- Study coordinator: Suresh, Kumar
Related research
Other NIH-funded projects on the same topics.
-
Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
A national effort to organize and share clinical data and biosamples from people with chronic pancreatitis, pancreatogenic diabetes, and pancreatic cancer to speed biomarker discovery and new treatments.
-
Lymphatic roles in pancreatitis and recovery
This project looks at how the lymphatic system influences inflammation and healing in pancreatitis, using mouse models to identify new therapeutic targets.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
-
Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.