New treatments for non-alcoholic fatty liver disease
Them1 Inhibitors for the Management of Non-Alcoholic Fatty Liver Disease
This study is looking at new medicines that could help people with non-alcoholic fatty liver disease by targeting a specific enzyme to improve how the body handles fat and reduce liver inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11084502 on NIH RePORTER |
What this research studies
This research focuses on developing new medications to treat non-alcoholic fatty liver disease (NAFLD) by targeting a specific enzyme called Them1, which plays a crucial role in fat metabolism. The approach involves creating small molecule inhibitors that can improve the body's ability to manage fat and reduce liver inflammation. The research will test these inhibitors in laboratory settings, including cell cultures and animal models, to ensure they are safe and effective. If successful, these treatments could help patients with NAFLD manage their condition more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic fatty liver disease.
Not a fit: Patients with alcoholic liver disease or other liver conditions unrelated to fatty liver may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new, effective treatments for patients suffering from non-alcoholic fatty liver disease.
How similar studies have performed: Previous research has shown promise in targeting similar metabolic pathways for treating liver diseases, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cohen, David E. — Brigham and Women's Hospital
- Study coordinator: Cohen, David E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.