New treatments for neuroblastoma in children
Novel Therapeutic Approaches for the Treatment of Neuroblastoma
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10977341
This study is looking for new ways to treat neuroblastoma, a tough cancer that mostly affects kids, by exploring how certain gene changes can be used to make treatments more effective.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10977341 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative therapies for neuroblastoma, a type of aggressive cancer that primarily affects children. The team is investigating the relationship between specific genetic mutations, particularly the MYCN oncogene and ATRX tumor-suppressor gene, to identify how these mutations can be targeted for treatment. By using human cell lines and mouse models, they aim to exploit the vulnerabilities created by these mutations to improve patient outcomes. The approach includes using targeted therapies that disrupt the cancer cells' ability to survive and grow.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with high-risk or recurrent neuroblastoma.
Not a fit: Patients with neuroblastoma who do not have MYCN amplification or ATRX mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for children with high-risk neuroblastoma, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promising results in targeting genetic vulnerabilities in cancers, suggesting that this approach could be effective for neuroblastoma as well.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DYER, MICHAEL A — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: DYER, MICHAEL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.