New treatments for neuroblastoma in children
Novel Therapeutic Approaches for the Treatment of Neuroblastoma
This study is looking for new ways to treat neuroblastoma, a tough cancer that mainly affects kids, by understanding how certain gene changes make the cancer worse, so they can create better treatments to help children live longer and healthier lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10817046 on NIH RePORTER |
What this research studies
This research focuses on developing innovative therapies for neuroblastoma, a type of aggressive cancer primarily affecting children. The team is investigating the relationship between specific genetic mutations, such as MYCN amplification and ATRX inactivation, which are linked to poor outcomes in patients. By using human cell lines and mouse models, they aim to exploit the vulnerabilities created by these mutations to create targeted treatments that can improve survival rates for children with high-risk neuroblastoma. The approach involves disrupting the processes that allow these cancer cells to thrive, potentially leading to more effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with high-risk or recurrent neuroblastoma.
Not a fit: Patients with neuroblastoma who do not have MYCN amplification or ATRX mutations may not benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better survival rates for children diagnosed with high-risk neuroblastoma.
How similar studies have performed: Previous research has shown promise in targeting genetic vulnerabilities in cancers, suggesting that this approach could be effective, although the specific combination being studied here is novel.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Dyer, Michael a — St. Jude Children's Research Hospital
- Study coordinator: Dyer, Michael a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.