New treatments for lymphatic malformations in children
Next Generation Treatments for Lymphatic Malformations
['FUNDING_R01'] · ARKANSAS CHILDREN'S HOSPITAL RES INST · NIH-11053505
This study is looking for new ways to treat cystic lymphatic malformations in children by understanding the genes and molecules in the affected cells, so we can create personalized treatments that work better and have fewer side effects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ARKANSAS CHILDREN'S HOSPITAL RES INST (nih funded) |
| Locations | 1 site (LITTLE ROCK, UNITED STATES) |
| Trial ID | NIH-11053505 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative treatments for cystic lymphatic malformations (LMs), which are congenital conditions that can cause severe complications in children, particularly affecting the neck and airway. The approach involves analyzing the genetic and molecular characteristics of LM cells to identify targeted therapies that could reduce the size of these malformations and improve patient outcomes. By utilizing advanced techniques such as RNA sequencing and proteomic analysis, the research aims to create personalized treatment plans that are more effective and have fewer side effects than current options.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with cystic lymphatic malformations.
Not a fit: Patients with lymphatic malformations who are older than 11 years or have other unrelated health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for children suffering from lymphatic malformations, significantly improving their quality of life.
How similar studies have performed: Previous research has shown promise in targeting genetic mutations associated with lymphatic malformations, indicating that this approach could yield significant advancements in treatment.
Where this research is happening
LITTLE ROCK, UNITED STATES
- ARKANSAS CHILDREN'S HOSPITAL RES INST — LITTLE ROCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STRUB, GRAHAM M — ARKANSAS CHILDREN'S HOSPITAL RES INST
- Study coordinator: STRUB, GRAHAM M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.