New treatments for lymphatic malformations in children
Official title: Next Generation Treatments for Lymphatic Malformations
Funded at Arkansas Children's Hospital Res Inst · NIH-11053505 · Data updated 2026-11-12
This study is looking for new ways to treat cystic lymphatic malformations in children by understanding the genes and molecules in the affected cells, so we can create personalized treatments that work better and have fewer side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $576,324 |
| NIH project number | 5R01HL173107-02 |
| Project ID | NIH-11053505 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old who have been diagnosed with cystic lymphatic malformations.
✕Less likely to help
Patients with lymphatic malformations who are older than 11 years or have other unrelated health issues may not benefit from this research.
What this research studies
This research focuses on developing innovative treatments for cystic lymphatic malformations (LMs), which are congenital conditions that can cause severe complications in children, particularly affecting the neck and airway. The approach involves analyzing the genetic and molecular characteristics of LM cells to identify targeted therapies that could reduce the size of these malformations and improve patient outcomes. By utilizing advanced techniques such as RNA sequencing and proteomic analysis, the research aims to create personalized treatment plans that are more effective and have fewer side effects than current options.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for children suffering from lymphatic malformations, significantly improving their quality of life.
How similar studies have gone: Previous research has shown promise in targeting genetic mutations associated with lymphatic malformations, indicating that this approach could yield significant advancements in treatment.
Where this research is happening
-
Arkansas Children's Hospital Res Inst
Little Rock, United States Active
Researchers
- Principal investigator: Strub, Graham M — Arkansas Children's Hospital Res Inst
- Study coordinator: Strub, Graham M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.