New treatments for drug-resistant seizures using WNT-pathway modulators
Investigational WNT-pathway modulators for the treatment and prevention of drug-resistant seizures
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-10911356
This study is exploring new ways to help people with epilepsy who have seizures that don't respond to regular medications, by testing existing drugs that might improve seizure control and prevent epilepsy from getting worse.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10911356 on ClinicalTrials.gov |
What this research studies
This research investigates innovative therapies targeting the WNT signaling pathway to treat and prevent drug-resistant seizures in patients with epilepsy. By utilizing established animal models, the study aims to identify effective agents that can improve seizure control and potentially prevent the onset of epilepsy. The approach focuses on repurposing existing medications that interact with molecular targets crucial for nervous system health. If successful, this research could lead to better treatment options for individuals who do not respond to current epilepsy medications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who experience drug-resistant epilepsy.
Not a fit: Patients who have well-controlled seizures with existing medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new, effective treatment options for patients suffering from drug-resistant seizures.
How similar studies have performed: Previous research has successfully identified effective treatments for epilepsy using similar animal model approaches, indicating potential for success in this study.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARKER-HALISKI, MELISSA LEIGH — UNIVERSITY OF WASHINGTON
- Study coordinator: BARKER-HALISKI, MELISSA LEIGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.