New treatments for chronic low back pain using engineered cell therapies
Novel non-viral reprogramming strategies to treat Discogenic back pain via engineered extracellular vesicles
This study is exploring a new way to help people with chronic low back pain by using special tiny particles to heal the damaged discs in their backs, offering a safer and less invasive treatment option that could help reduce pain without relying on addictive medications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11015895 on NIH RePORTER |
What this research studies
This research focuses on developing innovative therapies to treat chronic low back pain, which is often caused by degeneration of the intervertebral discs. The approach involves using engineered extracellular vesicles to reprogram degenerate cells in the discs, aiming to restore their healthy function and reduce pain. By targeting the underlying causes of pain rather than just the symptoms, this research seeks to provide a minimally invasive and non-addictive treatment option. Patients may benefit from a new way to manage their pain without relying on opioids.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic low back pain due to intervertebral disc degeneration.
Not a fit: Patients with acute back pain or those whose pain is not related to intervertebral disc degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel, non-addictive treatment for chronic low back pain that addresses the root causes of the condition.
How similar studies have performed: While this approach is innovative, similar strategies targeting cellular reprogramming for pain management have shown promise in preliminary studies.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Purmessur (Walter), Devina — Ohio State University
- Study coordinator: Purmessur (Walter), Devina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.