New treatments for brain metastasis in cancer patients
Developing new therapeutic strategies for brain metastasis
This study is looking at how cancer spreads to the brain, especially in patients with melanoma, lung cancer, and breast cancer, to see if treatments for Alzheimer’s disease can help fight these brain tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11008918 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind brain metastasis in cancer patients, particularly those with melanoma, lung, and breast adenocarcinomas. By developing a model using patient-derived cultures, the researchers aim to understand how brain metastases differ from other types of metastases. They are exploring the role of amyloid-beta (Aβ) in brain metastasis and hypothesize that existing Alzheimer’s treatments targeting Aβ can be repurposed to combat brain metastasis. The study employs advanced techniques such as proteomics and in vitro assays to identify potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients diagnosed with melanoma, lung, or breast adenocarcinoma who are at risk of developing brain metastasis.
Not a fit: Patients with brain metastasis from cancers other than melanoma, lung, or breast adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with brain metastasis, potentially improving survival rates and quality of life.
How similar studies have performed: Other research has shown promise in repurposing Alzheimer’s treatments for different conditions, suggesting potential success for this novel approach.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Hernando, Eva — New York University School of Medicine
- Study coordinator: Hernando, Eva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.