New treatments for brain injury after stroke
Novel Targets and Therapeutic Interventions against Cerebral Ischemia-Reperfusion Injury
This study is testing a new treatment for people who have had a stroke, using a special molecule to help protect their brain cells from damage and improve recovery after the stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11127524 on NIH RePORTER |
What this research studies
This research focuses on developing a novel therapeutic approach to address cerebral ischemia-reperfusion injury, a significant complication following acute ischemic stroke. The study aims to utilize a specific microRNA, miR-30c, which has been shown to decrease in levels after a stroke, to protect brain cells from damage. By administering a synthetic version of this microRNA through an intravenous injection, the researchers hope to mitigate the harmful effects of stroke and improve recovery outcomes. The approach targets multiple harmful processes that occur during and after a stroke, potentially leading to better treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults who have experienced an acute ischemic stroke and are facing the risk of cerebral ischemia-reperfusion injury.
Not a fit: Patients who have not experienced a stroke or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and outcomes for stroke patients.
How similar studies have performed: Previous research has shown promise in using microRNA therapies for various conditions, suggesting potential success for this novel approach.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Li, Guohong — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Li, Guohong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.