New treatments for advanced brain tumors using microRNA therapies
microRNA therapies for advanced brain tumors
This study is looking at new ways to treat glioblastoma, a tough brain tumor, by using special tiny molecules called microRNAs delivered through stem cells to help fight the cancer after surgery, and it will also test if using more than one type of microRNA can make the treatment even better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10746847 on NIH RePORTER |
What this research studies
This research focuses on developing innovative therapies for glioblastoma, a highly aggressive brain tumor. It explores the use of microRNAs, specifically miR-124, delivered through neural stem cells to target and inhibit tumor growth. The approach involves local delivery of these microRNAs into the tumor site after surgical removal, aiming to enhance the immune response against remaining cancer cells. The study will also investigate the combined effects of additional microRNAs to improve treatment efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who have undergone surgical resection of their tumors.
Not a fit: Patients with other types of brain tumors or those who are not eligible for surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Other research has shown promise in using microRNA therapies for cancer treatment, indicating potential for success in this novel approach.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Bhere, Deepak — University of South Carolina at Columbia
- Study coordinator: Bhere, Deepak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.