New treatments for a severe lung condition in infants
Development of novel therapeutic approaches for treatment of Alveolar Capillary Dysplasia
This study is looking for new ways to help newborns with a serious lung condition called ACDMPV by finding ways to grow better blood vessels in their lungs, which could help them breathe easier and live healthier lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10795953 on NIH RePORTER |
What this research studies
This research focuses on developing innovative therapies for Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV), a life-threatening condition in newborns that leads to severe respiratory issues. The team is investigating ways to stimulate the growth of blood vessels in the lungs to improve oxygen delivery and overall lung function. Using a mouse model that mimics the human condition, they will explore how enhancing lung angiogenesis can reduce complications like pulmonary arterial hypertension and improve survival rates for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are neonates and infants diagnosed with Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins.
Not a fit: Patients with other forms of chronic lung disease that are not related to ACDMPV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that significantly improve the survival and quality of life for infants with ACDMPV.
How similar studies have performed: While research on ACDMPV is limited, similar approaches targeting lung angiogenesis have shown promise in other conditions, suggesting potential for success in this area.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Kalinichenko, Vladimir — University of Arizona
- Study coordinator: Kalinichenko, Vladimir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.