New treatment to stop bone loss in severe gum disease
Novel therapy to prevent alveolar bone loss in severe periodontitis
This study is testing a new treatment to help prevent bone loss in your jaw caused by severe gum disease, using a special antibody to target certain proteins, and it's designed for adults dealing with this common issue.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Panorama Research, INC. NIH-funded |
| Lab location | 1 site (Sunnyvale, United States) |
| Project ID | NIH-10822066 on NIH RePORTER |
What this research studies
This research focuses on developing a novel therapy aimed at preventing alveolar bone loss associated with severe periodontitis, a common gum disease affecting many adults. The approach involves targeting specific proteins that regulate the activity of osteoclasts, the cells responsible for bone degradation. By using a monoclonal antibody that inhibits the OC-STAMP protein, the research aims to reduce the progression of bone loss and ultimately preserve dental health. Patients may be monitored for changes in bone density and overall gum health as part of the treatment evaluation.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with severe periodontitis and experiencing significant alveolar bone loss.
Not a fit: Patients with mild gum disease or those who do not have periodontitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that helps preserve teeth and improve oral health for patients with severe periodontitis.
How similar studies have performed: Previous research has shown promise in targeting osteoclast activity for treating bone loss, suggesting that this approach may be effective.
Where this research is happening
Sunnyvale, United States
- Panorama Research, INC. — Sunnyvale, United States (Active)
Researchers
- Principal investigator: Larrick, James W — Panorama Research, INC.
- Study coordinator: Larrick, James W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.