New treatment to stop bone loss in severe gum disease
Official title: Novel therapy to prevent alveolar bone loss in severe periodontitis
Funded at Panorama Research, INC. · NIH-10822066 · Data updated 2026-11-12
This study is testing a new treatment to help prevent bone loss in your jaw caused by severe gum disease, using a special antibody to target certain proteins, and it's designed for adults dealing with this common issue.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Panorama Research, INC. NIH-funded |
| Lab location | 1 site (Sunnyvale, United States) |
| Project start | August 15, 2024 |
| Project end | August 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $304,019 |
| NIH project number | 1R43DE033577-01 |
| Project ID | NIH-10822066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with severe periodontitis and experiencing significant alveolar bone loss.
✕Less likely to help
Patients with mild gum disease or those who do not have periodontitis may not benefit from this research.
What this research studies
This research focuses on developing a novel therapy aimed at preventing alveolar bone loss associated with severe periodontitis, a common gum disease affecting many adults. The approach involves targeting specific proteins that regulate the activity of osteoclasts, the cells responsible for bone degradation. By using a monoclonal antibody that inhibits the OC-STAMP protein, the research aims to reduce the progression of bone loss and ultimately preserve dental health. Patients may be monitored for changes in bone density and overall gum health as part of the treatment evaluation.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that helps preserve teeth and improve oral health for patients with severe periodontitis.
How similar studies have gone: Previous research has shown promise in targeting osteoclast activity for treating bone loss, suggesting that this approach may be effective.
Where this research is happening
-
Panorama Research, INC.
Sunnyvale, United States Active
Researchers
- Principal investigator: Larrick, James W — Panorama Research, INC.
- Study coordinator: Larrick, James W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.