New treatment to protect the brain after a stroke in diabetic patients
Official title: Novel Pharmacological Approach to Stroke Neuroprotection
Funded at University of Tennessee Health Sci Ctr · NIH-11022258 · Data updated 2026-11-12
This study is looking at a new treatment that might help protect the brain after a stroke, especially for people with Type 2 diabetes, by using a special molecule to keep brain cells healthy and improve recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $459,111 |
| NIH project number | 1R01NS140100-01 |
| Project ID | NIH-11022258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Type 2 diabetes who are at risk of or have experienced an acute ischemic stroke.
✕Less likely to help
Patients without diabetes or those who have not experienced a stroke may not benefit from this research.
What this research studies
This research investigates a novel pharmacological approach to protect the brain from damage after a stroke, particularly in patients with Type 2 diabetes. It focuses on a small molecule called CDN1163 that activates a protein known as SERCA2, which helps regulate calcium levels in brain cells. By restoring normal calcium homeostasis, the treatment aims to reduce cell death and improve recovery from stroke-related complications. The study will involve animal models to assess the effectiveness of this treatment in preventing neurovascular damage.
Why it matters
Potential benefit: If successful, this research could lead to a new therapy that significantly improves recovery and reduces complications for diabetic patients who suffer a stroke.
How similar studies have gone: Previous research has shown promising results with similar approaches targeting calcium homeostasis in stroke recovery, indicating potential for success in this novel treatment.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Lebeche, Djamel — University of Tennessee Health Sci Ctr
- Study coordinator: Lebeche, Djamel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.