New treatment to improve outcomes for Hispanic children with leukemia
Novel targeted therapy to reduce health disparities in pediatric leukemia
['FUNDING_R01'] · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · NIH-11080906
This study is looking at how to improve treatment for Hispanic and Latino children with B-cell acute lymphoblastic leukemia (B-ALL), who often have a harder time responding to chemotherapy, by testing a new therapy that targets specific genetic factors to help them have better chances of recovery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIV HERSHEY MED CTR (nih funded) |
| Locations | 1 site (HERSHEY, UNITED STATES) |
| Trial ID | NIH-11080906 on ClinicalTrials.gov |
What this research studies
This research focuses on addressing the higher death rates from B-cell acute lymphoblastic leukemia (B-ALL) in Hispanic/Latino children compared to non-Hispanic whites. It investigates the genetic factors, specifically the deletion of one IKZF1 allele, that contribute to poorer responses to chemotherapy in this population. By developing a targeted therapy using a CK2-specific inhibitor, the research aims to enhance the effectiveness of existing treatments and reduce health disparities. Patients will be treated with this novel approach to improve their chances of survival and recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are Hispanic/Latino children and adolescents diagnosed with B-cell acute lymphoblastic leukemia.
Not a fit: Patients who are not of Hispanic/Latino descent or those with other types of leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Hispanic children with leukemia, ultimately improving their survival rates.
How similar studies have performed: Previous research has shown promise in targeting genetic factors in leukemia treatment, suggesting that this approach could be effective.
Where this research is happening
HERSHEY, UNITED STATES
- PENNSYLVANIA STATE UNIV HERSHEY MED CTR — HERSHEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOVAT, SINISA — PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- Study coordinator: DOVAT, SINISA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.