New treatment to help regenerate cartilage in osteoarthritis patients
Official title: Treatment and prevention of osteoarthritis with an intra-articular disease-modifying regenerative therapy
Funded at Regenosine INC · NIH-10919932 · Data updated 2026-11-12
This study is testing a new treatment that uses a special form of adenosine to help rebuild cartilage in people with osteoarthritis, aiming to improve joint function and tackle the root of the problem instead of just easing the pain.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Regenosine INC NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | August 5, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $398,415 |
| NIH project number | 1SB1AR084381-01 |
| Project ID | NIH-10919932 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with osteoarthritis, particularly those experiencing significant joint pain and functional limitations.
✕Less likely to help
Patients with osteoarthritis who are not experiencing significant symptoms or those who have already undergone joint replacement surgery may not benefit from this research.
What this research studies
This research focuses on developing a novel therapy using a liposomal formulation of adenosine to regenerate cartilage in patients suffering from osteoarthritis (OA). The approach involves intra-articular injections aimed at reversing cartilage loss and improving joint function. By targeting the underlying mechanisms of OA, the therapy seeks to provide a disease-modifying solution rather than just symptomatic relief. The research builds on promising preclinical results showing significant improvements in joint health in animal models.
Why it matters
Potential benefit: If successful, this research could lead to a groundbreaking treatment that not only alleviates symptoms of osteoarthritis but also regenerates damaged cartilage, improving patients' quality of life.
How similar studies have gone: While the approach of using adenosine for cartilage regeneration is novel, preliminary studies in animal models have shown promising results, indicating potential for success in human applications.
Where this research is happening
-
Regenosine INC
Princeton, United States Active
Researchers
- Principal investigator: Angle, Siddhesh — Regenosine INC
- Study coordinator: Angle, Siddhesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.