New treatment targets for lung cancer
Targets for Therapy for Carcinomas of the Lung
This project looks for molecular weak points in different kinds of lung cancer to guide better treatments for people with the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11265089 on NIH RePORTER |
What this research studies
If you have lung cancer, this project aims to find the specific genes and pathways that drive different tumor types so therapies can be tailored. The team will study patient tumor samples alongside lab and animal models to identify promising targets and test drugs that hit those targets. They will also look closely at how tumors quickly adapt or develop resistance so treatments can work longer. The work combines clinical samples, molecular analysis, and preclinical testing to move promising findings toward new treatment options.
Who could benefit from this research
Good fit: People with lung cancer, especially those willing to provide tumor samples or enroll in related trials at Memorial Sloan Kettering or partner sites, would be typical candidates.
Not a fit: People without lung cancer or those whose tumors lack the specific molecular targets under study may not receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could produce more effective, personalized therapies that control tumors longer and reduce lung cancer deaths.
How similar studies have performed: Previous targeted therapies for specific lung cancer mutations (for example, EGFR and ALK) have succeeded, but many strategies to prevent or overcome resistance remain experimental.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Lito, Piro — Sloan-Kettering Inst Can Research
- Study coordinator: Lito, Piro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.