New treatment options for babesiosis using fosinopril analogs
Fosinopril analogs for the treatment of human babesiosis
This study is looking at a new treatment for babesiosis, a tick-borne illness, by testing a medication called fosinopril to see if it can help people feel better when current treatments don't work well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11059884 on NIH RePORTER |
What this research studies
This research focuses on developing new therapies for babesiosis, a tick-borne illness caused by parasites. Current treatments often fail or cause adverse effects, highlighting the need for better options. The researchers have identified fosinopril, an ACE inhibitor, as a promising candidate that has shown effectiveness in laboratory and animal models. By utilizing a continuous culture system for the parasites, they aim to explore the potential of fosinopril analogs to improve treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with babesiosis, particularly those who have not responded well to current treatments.
Not a fit: Patients with babesiosis who are already effectively treated with existing therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients suffering from babesiosis.
How similar studies have performed: While there have been studies on babesiosis treatments, the specific use of fosinopril analogs represents a novel approach that has not been extensively tested.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Ben Mamoun, Choukri — Yale University
- Study coordinator: Ben Mamoun, Choukri
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.