New treatment method for neonatal hydrocephalus using targeted biologics
Official title: Novel Biologics to ablate choroid plexus for the treatment of neonatal hydrocephalus
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10972862 · Data updated 2026-11-12
This study is exploring a new, gentler way to treat babies with hydrocephalus by targeting the part of the brain that makes too much fluid, using advanced techniques to see if it can help improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 17, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $394,544 |
| NIH project number | 1R61NS138647-01 |
| Project ID | NIH-10972862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants diagnosed with neonatal hydrocephalus who may benefit from innovative treatment approaches.
✕Less likely to help
Patients with hydrocephalus who are older than 21 years or those who have already undergone irreversible surgical interventions may not benefit from this research.
What this research studies
This research investigates a novel approach to treat neonatal hydrocephalus by developing a less invasive method to ablate the choroid plexus, which is responsible for producing cerebrospinal fluid. The team will utilize advanced techniques, including adeno-associated virus vectors and human organoid models, to deliver a clinically validated suicide gene specifically to the choroid plexus. By conducting experiments in rodent models and employing advanced imaging techniques, the research aims to evaluate the efficacy and safety of this new treatment method. This could potentially lead to improved outcomes for infants suffering from this condition.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for infants with neonatal hydrocephalus, reducing the need for invasive surgeries.
How similar studies have gone: While there have been advancements in hydrocephalus treatment, this specific approach using targeted biologics is novel and has not been extensively tested in clinical settings.
Where this research is happening
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Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Goto, June — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Goto, June
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.