New treatment for vascular aging and related dementias
Official title: Anti-medin immunotherapy for vascular aging and related dementias
Funded at Arizona Veterans Research and Education Foundation · NIH-10724869 · Data updated 2026-11-12
This study is testing a new treatment that uses a vaccine and antibodies to help reduce a harmful substance in blood vessels, which could improve brain health and memory for people facing age-related cognitive decline and dementia.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona Veterans Research and Education Foundation NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $380,060 |
| NIH project number | 1R21AG083558-01 |
| Project ID | NIH-10724869 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cognitive decline or at risk for vascular dementia.
✕Less likely to help
Patients with non-vascular forms of dementia or those not experiencing cognitive decline may not benefit from this research.
What this research studies
This research investigates a novel immunotherapy targeting medin, a peptide linked to vascular aging and dementia. The approach involves creating a vaccine and monoclonal antibodies to reduce medin accumulation in blood vessels, which may improve vascular health and cognitive function. By examining the efficacy of these treatments in preclinical models, the research aims to provide insights into how to combat age-related cognitive decline. Patients may benefit from a new therapeutic option that addresses the underlying vascular issues associated with dementia.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that improves cognitive function and vascular health in aging patients.
How similar studies have gone: While the specific approach of targeting medin is novel, similar immunotherapy strategies have shown promise in other areas of dementia research.
Where this research is happening
-
Arizona Veterans Research and Education Foundation
Phoenix, United States Active
Researchers
- Principal investigator: Migrino, Raymond Quezon — Arizona Veterans Research and Education Foundation
- Study coordinator: Migrino, Raymond Quezon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.