New treatment for stimulant use disorders
PTPRD Phosphatase inhibitors for stimulant use disorders
['FUNDING_OTHER'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11085789
This study is testing a new drug called pentilludin to see if it can help people struggling with stimulant use, like cocaine and amphetamines, by making those drugs less rewarding, and it's currently being tested in animals before moving on to humans.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11085789 on ClinicalTrials.gov |
What this research studies
This research investigates a novel drug, pentilludin, aimed at helping individuals with stimulant use disorders, such as those involving cocaine and amphetamines. The study focuses on how pentilludin works by inhibiting a specific enzyme, PTPRD, which is believed to reduce the rewarding effects of stimulants. By testing this drug in animal models, researchers aim to gather evidence on its effectiveness and safety before considering human trials. The ultimate goal is to develop a new pharmacotherapy that can assist patients in achieving and maintaining abstinence from stimulant use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with stimulant use disorders, including those who use cocaine or amphetamines.
Not a fit: Patients who do not have stimulant use disorders or who are not seeking treatment for such conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to an FDA-approved medication that helps individuals overcome stimulant use disorders.
How similar studies have performed: While stimulant use disorders are a significant challenge, this approach using PTPRD inhibitors is novel and has not been extensively tested in clinical settings.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UHL, GEORGE RICHARD — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: UHL, GEORGE RICHARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Attention deficit hyperactivity disorder