New treatment for nicotine addiction using e-vape technology.
Official title: Revolutionizing Nicotine Vaping and Electronic Nicotine Delivery Systems Addiction Treatment through Innovative E-Vape Administration of Cytisine to Enhance Patient Adherence and Treatment Completion.
Funded at Spacerx LLC · NIH-11008626 · Data updated 2026-11-12
This study is testing a new way to help people quit smoking or vaping by using a medication called cytisine in e-vape devices, making it easier for those who have tried to quit before to stick with their treatment.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Spacerx LLC NIH-funded |
| Lab location | 1 site (Reston, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $320,000 |
| NIH project number | 1R43DA061725-01 |
| Project ID | NIH-11008626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults and adolescents who are dependent on nicotine and have previously attempted to quit without success.
✕Less likely to help
Patients who are not currently using nicotine products or those who have successfully quit smoking or vaping may not benefit from this research.
What this research studies
This research focuses on developing a novel treatment for nicotine addiction by using cytisine, a smoking cessation drug, administered through e-vape devices. The approach aims to enhance patient adherence and treatment completion by allowing individuals to self-administer the medication in a familiar format. The study targets those who have struggled with quitting smoking or vaping, particularly those who have made multiple unsuccessful attempts. By addressing both the physical and behavioral aspects of nicotine addiction, this research seeks to provide a more effective solution for cessation.
Why it matters
Potential benefit: If successful, this research could significantly improve the success rates of individuals trying to quit nicotine by providing a more accessible and effective treatment option.
How similar studies have gone: While the use of cytisine for smoking cessation has been explored, this specific approach using e-vape technology is innovative and has not been widely tested.
Where this research is happening
-
Spacerx LLC
Reston, United States Active
Researchers
- Principal investigator: Lee, Peter H — Spacerx LLC
- Study coordinator: Lee, Peter H
Related research
Other NIH-funded projects on the same topics.
-
Reducing Addiction Risk in High Schools Through Better Prevention Infrastructure
Aims to build a sustainable, school-based system to prevent opioid and other drug use among high school students, especially those at higher risk.
-
HEAL Data Platform to share addiction-related data across programs
A platform project to make HEAL data from many programs easier to find and use, helping researchers and clinicians access information about addiction in children and youth.
-
Cognitively-enhanced tDCS to reduce cocaine craving
A study to test whether real brain stimulation together with learning strategies can lessen craving in people with cocaine use disorder.
-
Yale center researching how tobacco products affect use and addiction in people
A Yale research center is studying how nicotine, flavor additives, and other ingredients in tobacco products influence people’s likelihood of starting and becoming addicted.
-
Atherosclerosis in cocaine addiction: imaging risk with PET/MR
This project uses PET/MR imaging to look for early artery disease in people with cocaine use disorder to help prevent strokes or other brain injuries.
-
Integrating long-acting PrEP into street medicine for people who use drugs
This project tests whether a long-acting HIV prevention shot (lenacapavir) can be feasibly and acceptably offered by street-based health teams to people who use drugs.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.