New treatment for infections around joint replacements
Official title: A novel therapeutic for the treatment of biofilms in periprosthetic joint infections
Funded at Qentoros, LLC · NIH-10923988 · Data updated 2026-11-12
This study is testing a new treatment called BIO-PLY™ to help people who get infections after joint replacement surgeries, with the hope that it can safely reduce infections and inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Qentoros, LLC NIH-funded |
| Lab location | 1 site (Blacksburg, United States) |
| Project start | September 7, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $300,000 |
| NIH project number | 5R41AI179543-02 |
| Project ID | NIH-10923988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have undergone total joint arthroplasty and are experiencing or at risk for periprosthetic joint infections.
✕Less likely to help
Patients who have not had joint replacement surgeries or those without infections may not benefit from this research.
What this research studies
This research focuses on developing a new treatment for periprosthetic joint infections (PJI), which are serious complications that can occur after joint replacement surgeries. The approach involves using a specially formulated product derived from platelet-rich plasma, known as BIO-PLY™, which has shown promise in reducing bacterial infections and inflammation in animal models. The study aims to evaluate the safety and effectiveness of this treatment in humans, potentially offering a more reliable solution for patients suffering from these infections.
Why it matters
Potential benefit: If successful, this research could significantly improve treatment outcomes for patients with periprosthetic joint infections, reducing the need for invasive surgeries and long-term antibiotic use.
How similar studies have gone: While the use of platelet-rich plasma in treating infections has shown variable results in previous studies, this specific formulation and approach is novel and has not been extensively tested in humans.
Where this research is happening
-
Qentoros, LLC
Blacksburg, United States Active
Researchers
- Principal investigator: Gilbertie, Jessica — Qentoros, LLC
- Study coordinator: Gilbertie, Jessica
Related research
Other NIH-funded projects on the same topics.
-
Nebulized BIO-PLY biologic for severe neutrophilic asthma in adults
A new inhaled biologic therapy called BIO-PLY™ is being developed to help adults with a severe, neutrophilic form of asthma who don’t respond well to standard medicines.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.