New treatment for fentanyl-related opioid use disorder using monoclonal antibodies

Who could benefit from this research

What this research studies

This research investigates a novel monoclonal antibody therapy designed to combat the harmful effects of fentanyl and its analogs, which are responsible for a significant number of overdose deaths. The therapy, known as CSX-1004, works by binding to fentanyl in the bloodstream, preventing it from affecting the brain and causing respiratory depression. The approach aims to provide a longer-lasting solution compared to existing treatments like naloxone, which can be less effective against potent fentanyl variants. Patients receiving this treatment would be monitored for its effectiveness and safety through intravenous administration.

Why it matters

Where this research is happening

• Mclean Hospital
  Belmont, United States Active

Researchers

• Principal investigator: Desai, Rajeev Indrajit — Mclean Hospital
• Study coordinator: Desai, Rajeev Indrajit

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.