New treatment for colorectal cancer using CF10
Official title: Improved Treatment of Colorectal Cancer with CF10
Funded at Deep Creek Pharma, LLC · NIH-10835053 · Data updated 2026-11-12
This study is testing a new DNA-based drug called CF10 to see if it works better and has fewer side effects than the standard treatment for advanced colorectal cancer, especially for patients who haven't had success with other therapies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Deep Creek Pharma, LLC NIH-funded |
| Lab location | 1 site (Yadkinville, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,018,545 |
| NIH project number | 5R42CA254834-03 |
| Project ID | NIH-10835053 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with locally advanced or metastatic colorectal cancer who have not responded to standard treatments.
✕Less likely to help
Patients with early-stage colorectal cancer or those who have not yet undergone treatment may not benefit from this research.
What this research studies
This research focuses on developing CF10, a novel DNA-based drug that aims to improve treatment outcomes for patients with colorectal cancer, particularly those with advanced or metastatic disease. The approach involves comparing CF10's effectiveness and safety against the standard treatment, 5-FU, in pre-clinical models. The goal is to demonstrate that CF10 can provide better survival rates and fewer side effects, making it a promising option for patients who have not responded to existing therapies.
Why it matters
Potential benefit: If successful, this research could lead to a more effective and safer treatment option for colorectal cancer patients.
How similar studies have gone: Previous research has shown promising results with similar DNA-based therapies, indicating potential for success in this novel approach.
Where this research is happening
-
Deep Creek Pharma, LLC
Yadkinville, United States Active
Researchers
- Principal investigator: Gmeiner, William H. — Deep Creek Pharma, LLC
- Study coordinator: Gmeiner, William H.
Related research
Other NIH-funded projects on the same topics.
-
Improving colorectal cancer screening and follow-up care.
This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.
-
Colorectal cancer prognosis through a broad, collaborative study
A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.
-
Ceramides and how they affect metabolism and colorectal cancer in adults
A study in adults with obesity-related health issues will explore how a fat-related molecule called ceramide influences metabolic problems and colorectal cancer risk.
-
Automated point-of-care DNA methylation test for colorectal cancer in LMICs
A fast, affordable blood test using DNA markers to help identify people at higher risk of colorectal cancer in low- and middle-income countries.
-
Rewiring Colorectal Cancer to Harness Therapeutic Hyperactivation
A Yale team is exploring brain-storming new ways to treat colorectal cancer by safely boosting certain cancer signaling pathways to kill cancer cells and by reshaping cancer cell states to improve responses to existing therapies.
-
Comparative modeling to guide colorectal cancer screening and care
A researcher team will use computer models to study how access to care, risk, and new screening options affect colorectal cancer outcomes and costs for adults in the US.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.