New treatment for chronic kidney disease using a special peptide
Official title: Novel Therapeutic for Kidney Failure: A Modified, Water-Soluble Orally-Active Caveolin-1 Scaffolding Domain Peptide with Improved Characteristics for Drug Development
Funded at Fibrotherapeutics, INC. · NIH-11005463 · Data updated 2026-11-12
This study is exploring a new pill that could help people with chronic kidney disease by improving kidney function and reducing damage, and it's designed to find out how safe and effective this treatment can be.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fibrotherapeutics, INC. NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $337,740 |
| NIH project number | 1R41DK141315-01 |
| Project ID | NIH-11005463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are suffering from chronic kidney disease or related conditions.
✕Less likely to help
Patients with acute kidney injury or those who do not have chronic kidney disease may not benefit from this research.
What this research studies
This research focuses on developing a new oral treatment for chronic kidney disease (CKD) using a modified peptide derived from caveolin-1, which has shown promise in reducing fibrosis and improving kidney function in preclinical models. The researchers aim to enhance the peptide's properties to make it more effective and suitable for drug development. By testing the peptide's efficacy in various models, they hope to establish a treatment that can reverse kidney damage and improve patient outcomes. The study will involve assessing the safety and effectiveness of this new compound in a controlled setting.
Why it matters
Potential benefit: If successful, this research could provide a novel oral treatment option that significantly improves kidney function and quality of life for patients with chronic kidney disease.
How similar studies have gone: Previous research has shown promising results with similar peptide-based therapies in other fibrotic diseases, indicating potential for success in this novel approach.
Where this research is happening
-
Fibrotherapeutics, INC.
Charleston, United States Active
Researchers
- Principal investigator: Hoffman, Stanley R — Fibrotherapeutics, INC.
- Study coordinator: Hoffman, Stanley R
Related research
Other NIH-funded projects on the same topics.
-
Improving Access to Kidney Care for People at Highest Risk of Kidney Failure
A patient-facing program to help people at high risk of kidney failure get timely nephrology care and options for kidney replacement.
-
Improving Access to Nephrology Care for People at Highest Risk of Kidney Failure
This grant aims to help adults with advanced kidney disease get timely nephrology care and better options for kidney replacement.
-
Easier access to kidney care for people at high risk of kidney failure
This program will use care teams, clinic changes, and patient support to help adults with advanced chronic kidney disease get timely specialist care, permanent dialysis access, and education before they need dialysis or a transplant.
-
Investigating the effects of low-dose vitamin D on kidney failure patients
This study is looking at how small amounts of vitamin D might help people with kidney failure who are on dialysis, especially in keeping their hearts healthy, and it aims to find the safest and most effective way to use vitamin D for managing bone and mineral issues in these patients.
-
Improving decision-making for older adults considering kidney transplants
This study is all about helping older adults who are thinking about getting a kidney transplant by listening to their experiences and those of their families and doctors, so we can make the process easier and more supportive for everyone involved.
-
Impact of Hurricane Maria on kidney care and patient outcomes in Puerto Rico
This study looks at how Hurricane Maria affected people with kidney failure in Puerto Rico by making it harder for them to get the dialysis they need, and it aims to understand how this has impacted their health and care over time, so we can better prepare for future disasters.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.