New treatment for cardiac arrest using VBI-1
Official title: Development of VBI-1 as a novel treatment protocol for outpatient cardiac arrest
Funded at Vivacelle Bio, INC. · NIH-10921818 · Data updated 2026-11-12
This study is testing a new treatment called VBI-1 for people who have had a cardiac arrest, aiming to improve blood flow and oxygen to the heart and brain during resuscitation to help them survive and reduce brain injury.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vivacelle Bio, INC. NIH-funded |
| Lab location | 1 site (Fort Wayne, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $279,569 |
| NIH project number | 1R41HL174360-01 |
| Project ID | NIH-10921818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have suffered a cardiac arrest and require immediate resuscitation interventions.
✕Less likely to help
Patients who are not experiencing cardiac arrest or those with pre-existing severe health conditions may not benefit from this research.
What this research studies
This research investigates a novel treatment protocol called VBI-1 for patients experiencing cardiac arrest, a critical condition that can lead to severe complications or death. The approach focuses on improving blood flow and oxygen delivery to the heart and brain during resuscitation, aiming to enhance survival rates and reduce brain injury. VBI-1 is a specially formulated solution that helps restore effective blood circulation and minimizes damage caused by the lack of oxygen. The study will involve testing this treatment in a controlled setting to evaluate its effectiveness compared to standard resuscitation fluids.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and recovery outcomes for patients who experience cardiac arrest.
How similar studies have gone: Previous studies have shown promising results with similar approaches in animal models, indicating potential for success in human applications.
Where this research is happening
-
Vivacelle Bio, INC.
Fort Wayne, United States Active
Researchers
- Principal investigator: Simpkins, Cuthbert Ormond — Vivacelle Bio, INC.
- Study coordinator: Simpkins, Cuthbert Ormond
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.