New treatment for brain metastases from melanoma
Official title: Immune Therapy for Brain Metastasis
Funded at Yale University · NIH-11059073 · Data updated 2026-11-12
This study is looking at how well a combination of two medications, pembrolizumab and bevacizumab, works for people with melanoma that has spread to the brain, aiming to find better treatment options for those facing this tough situation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 18, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $501,954 |
| NIH project number | 5R01CA269286-03 |
| Project ID | NIH-11059073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with melanoma who have untreated brain metastases.
✕Less likely to help
Patients with brain metastases from other types of cancer or those who have already received treatment for their brain metastases may not benefit from this research.
What this research studies
This research focuses on improving treatment options for patients with melanoma that has spread to the brain. It investigates the effectiveness of combining the PD-1 inhibitor pembrolizumab with bevacizumab in patients with untreated brain metastases. The study aims to understand the molecular and cellular mechanisms of brain metastasis and evaluate the safety and efficacy of this combination therapy. By utilizing advanced pre-clinical models and patient data, the research seeks to enhance treatment outcomes for this challenging condition.
Why it matters
Potential benefit: If successful, this research could provide a more effective treatment option for patients with melanoma brain metastases, potentially improving survival rates and quality of life.
How similar studies have gone: Other research has shown promising results with similar combination therapies in treating melanoma brain metastases, indicating potential for success in this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Jilaveanu, Lucia Beatrice — Yale University
- Study coordinator: Jilaveanu, Lucia Beatrice
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.