New Treatment Combinations for Metaplastic Breast Cancer
Dual targeting of PI3K and NOS pathways in Metaplastic BreastCancer (MBC)
This research explores a new combination of treatments for patients with metaplastic breast cancer, a rare and aggressive form of breast cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11141612 on NIH RePORTER |
What this research studies
Metaplastic breast cancer is a very aggressive type of breast cancer with limited treatment options and a poor outlook for patients. Current treatments often don't work well because there are few specific targets for drugs. This project looks at two important pathways, PI3K/AKT and NOS, that are often overactive in metaplastic breast cancer cells. By blocking both pathways at the same time, researchers hope to find a more effective way to stop tumor growth and improve patient outcomes.
Who could benefit from this research
Good fit: This research is focused on understanding and treating metaplastic breast cancer, particularly for patients who have limited treatment options.
Not a fit: Patients without metaplastic breast cancer or those whose cancer does not involve the PI3K/AKT and NOS pathways may not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatment options for patients with metaplastic breast cancer, where current therapies are often insufficient.
How similar studies have performed: Previous clinical trials targeting the NOS pathway in triple-negative breast cancer patients have shown promising results, and laboratory studies combining these treatments have reduced tumor growth.
Where this research is happening
Houston, United States
- Methodist Hospital Research Institute — Houston, United States (Active)
Researchers
- Principal investigator: Chang, Jenny C-N — Methodist Hospital Research Institute
- Study coordinator: Chang, Jenny C-N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.