New treatment approaches for pediatric T-cell leukemia
Clonal Therapy for Pediatric T-cell Acute Lymphoblastic Leukemia
This study is looking for better ways to treat kids with T-cell leukemia by exploring the differences in their cancer cells that make it hard for standard treatments to work, with the hope of finding new and more effective therapies to help them survive.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10923893 on NIH RePORTER |
What this research studies
This research focuses on improving treatment options for children with pediatric T-cell acute lymphoblastic leukemia (pT-ALL), a condition that currently has poor outcomes with standard chemotherapy. The study aims to understand the genetic and cellular diversity within the leukemia cells that contribute to treatment resistance and disease recurrence. By utilizing advanced techniques in pharmacology and single-cell biology, researchers hope to identify novel therapeutic strategies that target these resistant clones. This could lead to more effective treatments and better survival rates for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years diagnosed with pediatric T-cell acute lymphoblastic leukemia.
Not a fit: Patients with other types of leukemia or those outside the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and treatment outcomes for children with T-cell leukemia.
How similar studies have performed: Previous research has shown promise in targeting genetic diversity in leukemia, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Yu, Jiyang — St. Jude Children's Research Hospital
- Study coordinator: Yu, Jiyang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.