New treatment approaches for adenosquamous pancreatic cancer
New Therapuetics for Pancreatic Cancer
Testing treatment strategies that target the unique genetic and epigenetic features of adenosquamous pancreatic cancer to help people with this rare, aggressive tumor.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11348857 on NIH RePORTER |
What this research studies
Researchers are building the largest set of laboratory models of adenosquamous pancreatic cancer (ASCP) and comparing their DNA and epigenetic patterns with the more common pancreatic ductal adenocarcinoma (PDAC). They will look for differences in gene activity and chromatin accessibility that could be weak points for therapy. Promising targets will be tested in preclinical models to see if those differences can be used to slow or stop tumor growth. The work is centered at Mayo Clinic Rochester and uses patient-derived tumor samples and molecular profiling methods like ATAC-seq.
Who could benefit from this research
Good fit: People diagnosed with adenosquamous carcinoma of the pancreas (and possibly some patients with pancreatic ductal adenocarcinoma) could be asked to contribute tumor samples or clinical data.
Not a fit: Patients without ASCP or PDAC, or those seeking immediate proven therapies rather than participation in research, are unlikely to benefit directly from this preclinical work.
Why it matters
Potential benefit: Could identify new, more precise treatment options for people with adenosquamous pancreatic cancer and potentially improve survival.
How similar studies have performed: Genomic and epigenetic profiling has guided therapies in other cancers, but large, focused efforts on ASCP are novel and relatively untested.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Fernandez-Zapico, Martin Ernesto — Mayo Clinic Rochester
- Study coordinator: Fernandez-Zapico, Martin Ernesto
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.