New treatment approach for triple negative breast cancer using innovative drug delivery

Who could benefit from this research

What this research studies

This research focuses on developing a novel drug delivery system called CargocytesTM, which is designed to effectively target and treat triple negative breast cancer by delivering therapeutic agents directly to the tumor microenvironment. The approach aims to minimize side effects by ensuring that the drugs are concentrated where they are needed most, rather than affecting healthy tissues. CargocytesTM are engineered to have unique properties that allow them to navigate through the body and penetrate tumor tissues more effectively than traditional methods. This innovative platform could potentially enhance the efficacy of cancer treatments for patients with metastatic disease.

Why it matters

Where this research is happening

• Cytonus Therapeutics, INC.
  Columbus, United States Active

Researchers

• Principal investigator: Filardo, Edward J — Cytonus Therapeutics, INC.
• Study coordinator: Filardo, Edward J

Related research

Other NIH-funded projects on the same topics.

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• Co-Targeting IL-6 and CDK4/6 to Prevent TNBC in Women Veterans

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  NIH research Baltimore VA Medical Center · Baltimore, United States · NIH-11608792

• Linking heavy metal exposure to a tougher breast cancer type (TNBC)

  Aimed at understanding how heavy metals like cadmium might trigger a dangerous breast cancer type (TNBC) in people, especially those with BRCA1 risk, to identify possible future treatment strategies.

  NIH research University of Louisville · Louisville, United States · NIH-11567535

• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

  Researchers will study how dormant cancer cells in liver and skin metastases of triple-negative breast cancer become quiescent or wake up, using organ-on-chip models and single-cell analysis to map chromatin states.

  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

  A new cell therapy approach uses engineered macrophages with a CAR and Rac2 activation to target and kill triple-negative breast cancer cells expressing CSPG4.

  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.