New treatment approach for improving tissue damage in alcoholic hepatitis
Novel mechanism based treatment to improve tissue injury in alcoholic hepatitis
This study is looking at a new way to help people with alcoholic hepatitis who are also dealing with muscle loss and malnutrition, by understanding how losing muscle affects liver health and finding better treatments to help them recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10897189 on NIH RePORTER |
What this research studies
This research investigates a novel treatment strategy aimed at improving tissue injury in patients suffering from alcoholic hepatitis, particularly those experiencing malnutrition and muscle loss. The study focuses on understanding how sarcopenia, or the loss of skeletal muscle, exacerbates liver inflammation and damage. By exploring the mechanisms behind muscle metabolism and ammonia disposal in the liver, the research aims to develop targeted therapies that could enhance recovery and clinical outcomes for affected patients. The approach includes examining the role of specific receptors and proteins involved in muscle and liver interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcoholic hepatitis who also exhibit signs of malnutrition or muscle loss.
Not a fit: Patients with alcoholic hepatitis who do not have malnutrition or significant muscle loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with alcoholic hepatitis, potentially enhancing their recovery and quality of life.
How similar studies have performed: While targeting sarcopenia in alcoholic hepatitis is an innovative approach, similar mechanisms have shown promise in other studies, suggesting potential for success in this area.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Dasarathy, Srinivasan — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dasarathy, Srinivasan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.