New treatment approach for glioblastoma using nanoimmunodrugs
Official title: Targeting tumor microenvironment by nanoimmunodrugs for glioma treatment
Funded at Cedars-Sinai Medical Center · NIH-10931507 · Data updated 2026-11-12
This study is exploring a new way to treat glioblastoma, a tough type of brain cancer, by using tiny medicines that can reach the tumor and boost the body's immune response to fight it better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 19, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $512,558 |
| NIH project number | 5R01CA284247-02 |
| Project ID | NIH-10931507 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking new treatment options.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research focuses on developing a novel treatment for glioblastoma, the most aggressive form of brain cancer, by targeting the tumor microenvironment and enhancing the immune response in the brain. The approach utilizes advanced nanomedicines designed to effectively cross the blood-brain barrier, allowing for better delivery of therapeutic agents directly to the tumor site. By understanding the interactions between specific proteins in the tumor environment and the local immune system, the research aims to create a more effective treatment strategy that could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving survival rates and quality of life for patients.
How similar studies have gone: Other research has shown promise in using nanotechnology and immunotherapy for cancer treatment, suggesting that this approach could be effective.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Ljubimov, Alexander V — Cedars-Sinai Medical Center
- Study coordinator: Ljubimov, Alexander V
Related research
Other NIH-funded projects on the same topics.
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How RNA Splicing Might Shape Glioma Cell States and Therapy Response
A small NIH-funded project will study how alternative RNA splicing influences glioma cell identities and treatment resistance in patient-derived cells.
-
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A Mayo Clinic team tests a blood test that looks for unique tumor DNA pieces in glioblastoma patients to monitor disease without frequent scans.
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A study is exploring whether a brain cell pH regulator (Slc4a4) affects the growth and blood vessel changes of malignant glioma to identify new angles for treatment.
-
Predicting how gene therapy spreads in glioblastoma after surgery to improve treatment coverage
This project uses a gene therapy that helps radiation work better against glioblastoma and builds computer models to predict where the therapy reaches after surgical tumor removal.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.