New treatment approach for glioblastoma using a modified measles virus
Novel multipronged Immunovirotherapy Approach for GBM Treatment
This study is exploring a new treatment for glioblastoma, a tough type of brain cancer, by using a modified measles virus to help boost the immune system and work better with current cancer therapies, and it's designed for patients looking for new options to improve their treatment outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11041020 on NIH RePORTER |
What this research studies
This research investigates a novel immunovirotherapy approach for treating glioblastoma (GBM), a highly aggressive brain cancer. The study utilizes a modified strain of the measles virus that is designed to stimulate the immune system and enhance the effectiveness of existing cancer therapies. By combining this viral treatment with immune checkpoint inhibitors and other agents, the researchers aim to improve the tumor microenvironment and promote better patient outcomes. Patients may be treated in preclinical models that mimic human GBM to assess the safety and efficacy of this innovative therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who have not responded to standard treatments.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective treatment option for glioblastoma patients, potentially improving survival rates and quality of life.
How similar studies have performed: While immunotherapy for glioblastoma has faced challenges, this approach is based on promising preclinical data, suggesting potential for success in this novel application.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Galanis, Evanthia — Mayo Clinic Rochester
- Study coordinator: Galanis, Evanthia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.